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Event Information
Date
12/4/2009
Time
4:00 PM
Venue
Cooper Nursing Building
CN 160
CN 160
Audience
General Audience
Current Students
Faculty
Current Students
Faculty
Additional Information
Patrick P. Edger, University of Missouri-Columbia, Biological Sciences,
“Gene and Genome Duplications: The impact of dosage sensitivity on the fate of nuclear genes”
Ancient whole genome duplications (WGDs), inferred from analyzed sequenced genomes and comparative genomics, are prevalent and recurring throughout the evolutionary history of all higher eukaryotic lineages. By investigating the fates of nuclear genes after independent WGDs and smaller scale duplications (e.g. local, tandem, segmental, aneuploidy), researchers have been able to contrast the expansion of specific gene families and functional gene categories under different duplication mechanisms. In this seminar, the evidence from recent studies will be summarized, while focusing on how the Gene Balance Hypothesis, also called the Dosage Balance Hypothesis, provides a mechanism to predict the fate of nuclear gene duplicates (based on protein connectivity and biochemical function). The Gene Balance Hypothesis provides a unifying mechanism to explain the impact of duplications across various functional gene categories simultaneously both in the short term and over longer time periods. Genomic evidence from across eukaryotic lineages will be evaluated.
Contact Information
Name
Kemuel Badger, Chair
Phone
285-8820
Email
