October 5, 2023 3:30 p.m.End:
October 5, 2023 4:30 p.m.
Exploring the Diversity of RNA: From Natural Properties to Artificial Nucleic Acid Nanodevices
Dr. Emil Khisamutdinov (Sabbatical Talk)
Associate Professor, Department of Chemistry, Ball State University
Thursday, October 5th @ 3:30 PM
RNA molecules not only encode genetic information but also actively participate in various intracellular functions, including biocatalysis and the regulation of gene expression. This versatility highlights RNA as a functionally diverse molecule, leading to the hypothesis that RNA predates DNA and proteins. It is evident that RNA possesses capabilities beyond its traditional role in Francis Crick's central dogma of molecular biology. However, to fulfill its functions, RNA must adopt specific three-dimensional (3D) architectures. Inspired by natural 3D RNA complexes, there is a significant demand for the development of artificial RNA molecules with finely tuned biophysical and biochemical properties, particularly in field of therapeutic RNA nanotechnology. In this seminar, my objective is to provide insight into the diversity of in vitro studies and approaches that I have employed during my independent career as a faculty member at BSU. These approaches harness the inherent properties of RNAs, allowing for the creation of numerous artificial nucleic acid nanodevices with potential therapeutic and diagnostic applications.